"Me Muero" was officially released to American and Latin American radio towards the end of 2006. In Mexico, the song topped the official singles chart for eleven weeks in a row, eventually being succeeded by Julieta Venegas' "Eres para mi". In the United States, the song peaked at number two on the Latin Pop Airplay chart and number ten on the Hot Latin Tracks chart. In Spain, the song peaked at number two. According to Promusicae, "Me Muero" has been certified 6× Platinum in Spain for sales of over 120,000 units, being one of the big hits from 2007 in that country.

The song was recently[when?] re-done in a "Banda" style by Objetivo Fama finalist and Mexican singer "Azucena del Campo", and has been released to much acclaim.[citation needed]

The music video for "Me Muero" begins with what appears as a fan cutting and pasting pictures of a wrestling star. The collage album is then given to the wrestler and he reflects on it while he faces a match. La 5ª Estación is shown singing from the ring in the arena. The supposed fan then shows up to the match as sign of support. Finally a scene is shown where the two kiss and it is revealed that the fan was actually the wrestler's wife. The main wrestler in the video is professional Mexican wrestler, Místico.